聂海亮

一、个人简介

聂海亮，副教授，硕士生导师，河北省检验检疫学会理事；博士毕业于北京理工大学，主持国家自然科学基金、河北省自然科学基金，河北省高等学校科学技术研究项目等5项课题，发表学术论文20余篇，授权发明专利2项。

联系方式：E-mail: nhlggws@hbu.edu.cn       

二、主讲课程及研究方向 
1.主讲课程：食品理化检验、实验室安全与管理、现代卫生检验技术。
2.研究方向：卫生检验技术，分子荧光探针。

三、代表性论文

1．Chenchuang Tao, Chaojun Wang, Chaoyuan Zeng*, Linsen Li, Jie Bai, Hailiang Nie*. A highly selective ratiometric fluorescent probe for butyrylcholinesterase: Applications in quantification, residue screening, and toxicological studies of organophosphorus pesticides. Food Chemistry, 2025, 144143.

2．Xueping Yang, Taoran Li, Xu Chen, Huan Zhang, Chao Liu*, Chenchuang Tao, Hailiang Nie*. Tetraphenylethylene-indole as a novel fluorescent probe for selective and sensitive detection of human serum albumin (HSA) in biological matrices and monitoring of HSA purity and degradation. Talanta, 2025, 286: 127471.

3．Chaojun Wang, Wenjiao Zhao, Huan Zhang, Jie Bai, Jianling Chen, Hailiang Nie*. An ultrasensitive, selective pseudoesterase-activated fluorescent probe for monitoring acetylation modification, configuration transformation and biological levels of human serum albumin. Sensors and Actuators B: Chemical, 2024, 414: 135950. 

4．Cuixia Liang, Yumeng Wang, Tingting Zhang, Hailiang Nie*, Yanmei Han, Jie Bai*. Aptamer-functionalised metal-organic frameworks as an ‘on–off–on’ fluorescent sensor for bisphenol S detection, Talanta, 2023, 253: 123942.

5．Hailiang Nie*, Wenjia Ji, Jie Cui, Xiaomeng Liang, Xueping Yang, Jie Bai, Xiaoling Zhang*. An AIE luminogen self-assembled nanoprobe for efficient monitoring of the concentration and structural transition of human serum albumin. Analytica Chimica Acta, 2022, 1236: 340578.

6．Jie Cui, Hailiang Nie*, Xiaomeng Liang, Jie Bai, Xiaoling Zhang. A pyrene-derived ratiometric fluorescent probe for pH monitoring in cells and zebrafish based on monomer-excimer emission. Journal of Molecular Liquids, 2022, 366, 120325.

7．Meng Yao, Hailiang Nie*, Wenxue Yao, Xueping Yang, Guowei Zhang*. A sensitive and selective fluorescent probe for acetylcholinesterase: Synthesis, performance, mechanism and application. Arabian Journal of Chemistry, 2022, 15,  103929.

8．Xiaomeng Liang, Hailiang Nie*, Chunliu Yang, Zhenguang Wang, Jie Bai, Hongyuan Yan*. A cationic aggregation-induced emission luminogen for colorimetric and fluorimetric detection of heparin with a dual-read approach, stability and applicability in a 10% serum matrix. Journal of Molecular Liquids, 2021, 343: 117585.

9．Jie Cui, Hailiang Nie*, Shunping Zang, Sa Su, Mengxu Gao, Jing Jing*, Xiaoling Zhang*. A conformational transition based fluorescent probe for mapping lysosomal viscosity fluctuations by fluorescence lifetime imaging. Sensors and Actuators: B. Chemical, 2021, 328: 129432.

10．Jie Cui, Shunping Zang, Hailiang Nie*, Tiaojiao Shen, Sa Su, Jing Jing*, Xiaoling Zhang*. An ICT-based fluorescent probe for ratiometric monitoring the fluctuations of peroxynitrite in mitochondria. Sensors and Actuators: B. Chemical, 2021, 328: 129069.

11．Jie Cui, Shunping Zang, Wei Shu, Hailiang Nie*, Jing Jing*, Xiaoling Zhang*. Highly sensitive and selective detection of heparin in serum based on a long-wavelength tetraphenylethylene–cyanopyridine aggregation-induced emission luminogen. Analytical Chemistry, 2020, 92(10): 7106-7113.

12．Hailiang Nie, Yanhong Liang, Chuang Han, Rubo Zhang, Xiaoling Zhang*, Hongyuan Yan*. Rational design of cyanovinyl-pyrene dual-emission AIEgens for potential application in dual-channel imaging and ratiometric sensing in living cells. Dyes and Pigments, 2019, 168, 42-48.

13．Hailiang Nie, Liang Qiao, Wen Yang, Bingpeng Guo, Fangyun Xing, Jing Jing*, Xiaoling Zhang*. UV-assisted synthesis of long-wavelength Si-pyronine fluorescent dyes for real-time and dynamic imaging of glutathione fluctuation in living cells. Journal of Materials Chemistry B, 2016, 4(28): 4826-4831.

14．Hailiang Nie, Jing Jing, Yong Tian, Wen Yang, Rubo Zhang*, Xiaoling Zhang*. Reversible and dynamic fluorescence imaging of cellular redox self-regulation using fast-responsive near-infrared Ge-pyronines. ACS Applied Materials & Interfaces, 2016, 8(14): 8991-8997.

15．Hailiang Nie, Wen Yang, Mengqi Yang, Jing Jing*, Xiaoling Zhang*. Highly specific and ratiometric fluorescent probe for ozone assay in indoor air and living cells. Dyes and Pigments, 2016, 127: 67-72.

16．刘超, 杜柳铭, 聂心容, 房少洁, 聂海亮. 中国肺结核病的季节性特征、循环周期及长短期预测. 中国感染控制杂志, 2023, 22(7): 46-52.

四、科研项目

1. 国家自然科学基金青年项目（21807022），2019/01-2021/12，主持。

2．河北省自然科学基金青年项目（B2019201237），2019/01-2021/12, 主持。

3. 河北省高等学校科学技术研究项目（ZD2021009），2021/01-2023/12，主持。

4. 河北大学医学学科培育项目（2021A05），2021/01-2023/12, 主持。

五、授权专利

1.聂海亮、梁晓萌、闫宏远、白洁、张国伟、杨晓溪，一种芘基苯并咪唑类荧光探针及其制备方法和应用，专利号：ZL202110460745.6。

2.聂海亮、何志霄、闫宏远、王振光、杨春柳、刘树芳，一种广谱型蛋白质荧光探针及其制备方法和应用，专利号：ZL202110460757.9。

六、获奖情况

1.复杂体系中痕量危害因子精准快速卫生检测关键技术开发及应用，河北省科学技术进步奖二等奖，3/8，2023年。