聂海亮

一、个人简介

        聂海亮，副教授，硕士生导师，北京理工大学，博士；主持国家自然科学青年基金、河北省自然科学青年基金、河北省高等学校科学技术研究重点项目、河北大学医学学科培育重点项目等课题5项；以第一或通讯作者发表学术论文18篇；授权发明专利2项。

        联系方式：E-mail: nhlggws@hbu.edu.cn             

二、主讲课程及研究方向 

1.主讲课程：食品理化检验、实验室安全与管理、现代卫生检验技术等。

2.研究方向：公共卫生快速检测技术；荧光探针的设计与应用

三、代表性论文

1. Hailiang Nie*, Wenjia Ji, Jie Cui, Xiaomeng Liang, Xueping Yang, Jie Bai, Xiaoling Zhang*. An AIE luminogen self-assembled nanoprobe for efficient monitoring of the concentration and structural transition of human serum albumin. Analytica Chimica Acta, 2022, 1236, 340578.

2. Cuixia Liang, Yumeng Wang, Tingting Zhang, Hailiang Nie*, Yanmei Han, Jie Bai*. Aptamerfunctionalised metal-organic frameworks as an ‘on–off–on’ fluorescent sensor for bisphenol S detection, Talanta, 2022, 253, 123942.

3. Jie Cui, Hailiang Nie*, Xiaomeng Liang, Jie Bai, Xiaoling Zhang. A pyrene-derived ratiometric fluorescent probe for pH monitoring in cells and zebrafish based on monomer-excimer emission. Journal of Molecular Liquids, 2022, 366, 120325.

4. Meng Yao, Hailiang Nie*, Wenxue Yao, Xueping Yang, Guowei Zhang*. A sensitive and selective fluorescent probe for acetylcholinesterase: Synthesis, performance, mechanism and application. Arabian Journal of Chemistry, 2022, 15, 103929.

5. Xiaomeng Liang, Hailiang Nie*, Chunliu Yang, Zhenguang Wang, Jie Bai, Hongyuan Yan*. A cationic aggregation-induced emission luminogen for colorimetric and fluorimetric detection of heparin with a dual-read approach, stability and applicability in a 10% serum matrix. Journal of Molecular Liquids, 2021, 343: 117585.

6. Jie Cui, Hailiang Nie*, Shunping Zang, Sa Su, Mengxu Gao, Jing Jing*, Xiaoling Zhang*. A conformational transition based fluorescent probe for mapping lysosomal viscosity fluctuations by fluorescence lifetime imaging. Sensors and Actuators: B. Chemical, 2021, 328, 129432.

7. Jie Cui, Shunping Zang, Hailiang Nie*, Tiaojiao Shen, Sa Su, Jing Jing*, Xiaoling Zhang*. An ICT-based fluorescent probe for ratiometric monitoring the fluctuations of peroxynitrite in mitochondria. Sensors and Actuators: B. Chemical, 2021, 328, 129069.

8. Jie Cui, Shunping Zang, Wei Shu, Hailiang Nie*, Jing Jing*, Xiaoling Zhang*. Highly sensitive and selective detection of heparin in serum based on a long-wavelength tetraphenylethylene–cyanopyridine aggregation-induced emission luminogen. Analytical Chemistry, 2020, 92(10), 7106-7113.

9. Hailiang Nie, Yanhong Liang, Chuang Han, Rubo Zhang, Xiaoling Zhang*, Hongyuan Yan*. Rational design of cyanovinyl-pyrene dual-emission AIEgens for potential application in dual-channel imaging and ratiometric sensing in living cells. Dyes and Pigments, 2019, 168, 42-48. 

10. Hailiang Nie, Liang Qiao, Wen Yang, Bingpeng Guo, Fangyun Xing, Jing Jing*, Xiaoling Zhang*. UV-assisted synthesis of long-wavelength Si-pyronine fluorescent dyes for real-time and dynamic imaging of glutathione fluctuation in living cells. Journal of Materials Chemistry B, 2016, 4(28), 4826-4831.

11. Hailiang Nie, Jing Jing, Yong Tian, Wen Yang, Rubo Zhang*, Xiaoling Zhang*. Reversible and dynamic fluorescence imaging of cellular redox self-regulation using fast-responsive near-infrared Ge-pyronines. ACS Applied Materials & Interfaces, 2016, 8(14), 8991-8997.  

12. Hailiang Nie, Wen Yang, Mengqi Yang, Jing Jing*, Xiaoling Zhang*. Highly specific and ratiometric fluorescent probe for ozone assay in indoor air and living cells. Dyes and Pigments, 2016, 127, 67-72.

四、科研项目

1. 河北省高等学校科学技术研究重点项目（ZD2021009），2021/01-2023/12，在研，主持。

2. 河北大学医学学科培育项目（2021A05），2021/01-2023/12, 在研，主持

3. 国家自然科学基金青年项目(21807022），2019/01-2021/12，已结题，主持。

4. 河北省自然科学基金青年项目(B2019201237)，2019/01-2021/12, 已结题，主持。

五、授权专利

1．聂海亮、梁晓萌、闫宏远、白洁、张国伟、杨晓溪，一种芘基苯并咪唑类荧光探针及其制备方法和应用，专利号：ZL202110460745.6。

2．聂海亮、何志霄、闫宏远、王振光、杨春柳、刘树芳，一种广谱型蛋白质荧光探针及其制备方法和应用，专利号：ZL202110460757.9。