一、个人简介
聂海亮，副教授，硕士生导师，2017年毕业于北京理工大学，博士研究生。长期从事卫生快速检验技术和荧光传感器方面的研究，近年来主持国家自然科学基金青年基金1项、河北省自然科学基金青年基金1项，河北省高等学校科学技术研究重点项目1项，以第一作者或共同通讯作者发表SCI学术论文16篇，申请发明专利2项。
联系方式：Email: nhlggws@hbu.edu.cn
二、主讲课程及研究方向
1. 主讲课程：现代卫生检验技术、食品理化检验、实验室安全与管理等。2. 研究方向：卫生快速检验技术、荧光传感器。
三、代表性论文
1. Jie Cui, Hailiang Nie*, Xiaomeng Liang, Jie Bai, Xiaoling Zhang. A pyrene-derived ratiometric fluorescent probe for pH monitoring in cells and zebrafish based on monomer-excimer emission. Journal of Molecular Liquids, 2022, 366, 120325.
2. Cuixia Liang, Yumeng Wang, Tingting Zhang, Hailiang Nie*, Yanmei Han, Jie Bai*. Aptamer-functionalised metal-organic frameworks as an ‘on–off–on’ fluorescent sensor for bisphenol S detection. Talanta, 2022, 253, 123942.
3. Meng Yao, Hailiang Nie*, Wenxue Yao, Xueping Yang, Guowei Zhang*. A sensitive and selective fluorescent probe for acetylcholinesterase: Synthesis, performance, mechanism and application. Arabian Journal of Chemistry, 2022, 15, 103929.
4. Xiaomeng Liang, Hailiang Nie*, Chunliu Yang, Zhenguang Wang, Jie Bai, Hongyuan Yan*. A cationic aggregation-induced emission luminogen for colorimetric and fluorimetric detection of heparin with a dual-read approach, stability and applicability in a 10% serum matrix. Journal of Molecular Liquids, 2021, 343: 117585.
5. Zhixiao He, Hailiang Nie*, Jie Cui, Xiaoling Zhang, Xiaoxi Yang, Cuiping Li, Hongyuan Yan*. An electrostatically regulated organic selfassembly for rapid and sensitive detection of heparin in serum. Analytical Methods, 2021, 13: 3620-3626.
6. Jie Cui, Hailiang Nie*, Shunping Zang, Sa Su, Mengxu Gao, Jing Jing*, Xiaoling Zhang*. A conformational transition based fluorescent probe for mapping lysosomal viscosity fluctuations by fluorescence lifetime imaging. Sensors and Actuators: B. Chemical, 2021, 328: 129432.
7. Jie Cui, Shunping Zang, Hailiang Nie*, Tiaojiao Shen, Sa Su, Jing Jing*, Xiaoling Zhang*. An ICT-based fluorescent probe for ratiometric monitoring the fluctuations of peroxynitrite in mitochondria. Sensors and Actuators: B. Chemical, 2021, 328: 129069.
8. Jie Cui, Shunping Zang, Wei Shu, Hailiang Nie*, Jing Jing*, Xiaoling Zhang*. Highly sensitive and selective detection of heparin in serum based on a long-wavelength tetraphenylethylene–cyanopyridine aggregation-induced emission luminogen. Analytical Chemistry, 2020, 92(10): 7106-7113.
9. Haiyan Cao, Xiude Qin, Chen Liu, Xinzhe Zhao, Yuhui Ma, Jingna Zhou, Yu Liu, Shaoqin, Guowei Zhang*, Hailiang Nie*. Establishment of fluorescence sensitization method for Hydroxysafflor Yellow A. Evidence-Based Complementary and Alternative Medicine, 2020, 2020: 1-13.
10. Jie Cui, Lingzhi Cao, Guangshun Wang, Wenjia Ji, Hailiang Nie*, Chunliu Yang, Xiaoling Zhang*. A fast-responding, highly sensitive detection system consisting of a fluorescent probe and palladium ions for N2H4 in environmental water and living cells[J]. Analytical Methods, 2019, 11(39). 5023-5030.
11. Nie Hailiang, Liang Yanhong, Han Chuang, Zhang Rubo, Zhang Xiaoling, Yan Hongyuan; Rational design of cyanovinyl-pyrene dual-emission AIEgens for potential application in dual-channel imaging and ratiometric sensing in living cells; Dyes and Pigments; 2019, 168, 42-48.
12. Jie Cui, Guanqing Gao, Hengzhi, Zhao, Yazhou Liu, Hailiang Nie*, Xiaoling Zhang*, A highly sensitive and selective fluorescent probe for N2H4 in air and living cells, New Journal of Chemistry, 2017, 41, 11891-11897.
13. Hailiang Nie, Liang Qiao, Wen Yang, Bingpeng Guo, Fangyun Xing, Jing Jing*, Xiaoling Zhang*, UV-assisted synthesis of long-wavelength Si-pyronine fluorescent dyes for real-time and dynamic imaging of glutathione fluctuation in living cells, Journal of Materials Chemistry B, 2016, 4(28): 4826-4831.
14. Hailiang Nie, Jing Jing, Yong Tian, Wen Yang, Rubo Zhang*, Xiaoling Zhang*, Reversible and dynamic fluorescence imaging of cellular redox self-regulation using fast-responsive near-infrared Ge-pyronines, ACS Applied Materials & Interfaces, 2016, 8(14): 8991-8997.
15. Hailiang Nie, Wen Yang, Mengqi Yang, Jing Jing*, Xiaoling Zhang*, Highly specific and ratiometric fluorescent probe for ozone assay in indoor air and living cells, Dyes and Pigments, 2016, 127: 67-72.
16. Hailiang Nie, Junming Geng, Jing Jing, Yamin Li, Wen Yang*, Xiaoling Zhang*, Triphenylphosphine-Assisted Highly Sensitive Fluorescent Chemosensor for Ratiometric Detection of Palladium in Solution and Living Cells, RSC Advances, 2015, 5(118): 97121-97126.
四、科研项目
1．国家自然科学基金青年项目，基于双发射AIE染料的比率型分子/纳米荧光探针研究（21807022），2019/01-2021/12，已结题，主持。
2．河北省自然科学基金青年项目，近红外双发射AIE染料的设计合成及其在比率荧光探针构建中的应用（B2019201237），2019/01-2021/12, 已经题，主持。
3. 河北省高等学校科学技术研究重点项目，近红外比率型胆碱酯酶荧光探针在农残快检中的应用（ZD2021009），2021/01-2023/12，在研，主持。
五、专利
1. 聂海亮、梁晓萌、闫宏远、白洁、张国伟、杨晓溪，一种芘基苯并咪唑类荧光探针及其制备方法和应用，专利号：ZL202110460745.6。
2. 聂海亮、何志霄、闫宏远、王振光、杨春柳、刘树芳，一种广谱型蛋白质荧光探针及其制备方法和应用，专利号：ZL202110460757.9。